Effect of Genetically Modified Soybean Oil Consumption on Biochemical and Histological Changes of Liver and Kidney in Rats

Horyie Taheri 1, Mehran Mesgari-Abbasi 2, Monireh Khordadmehr 3, Alireza Rahimi Mamaghani 4, Mahdieh Abbasalizad-Farhangi 1* 

1 Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
2 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Pathology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
4 Clinical Research Development, Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Science, Tabriz, Iran

*Corresponding Author: Mahdieh Abbasalizad Farhangi, Email: abbasalizad_m@yahoo.com

Abstract

Background: The use of transgenic foods has increased global food production and food security. However, there are concerns about their potential negative impacts on health. Studies conducted on the effect of transgenic products on humans and animals are limited, and they do not provide an answer regarding the possible health hazards of transgenic products. Therefore, this study aimed to examine the effects of a diet containing genetically modified soybean oil on organ health and biochemical changes in an experimental model.

Methods: The current study was conducted on 18 male Wistar rats in three different groups (6 rats per group). One group was fed a diet containing %10 genetically modified soybean oil for 90 days, while the other two groups served as control groups, receiving either non-genetically modified soybean oil or a standard diet, respectively. Body weight and food consumption were measured once and three times a week, respectively.

Results: Our findings indicated that transgenic soybean oil contributed to several histological derangements, including congestion, necrosis, and bile duct hyperplasia in the liver analysis. Similarly, congestion, hemorrhage, and glomerulosclerosis were observed in the kidney analysis. Moreover, transgenic soybean oil significantly increased gamma-glutamyl transferase (GGT) (P=0.047) and insulin (P=0.048) levels compared to a standard diet. Furthermore, urea and triglycerides (TG) were significantly higher in genetically modified (GM)-fed rats compared to rats fed with standard or non-GM diet (P<0.001).

Conclusion: According to the results, a 90-day treatment with transgenic soy-based oil caused significant organ changes in the liver and kidneys of rats. Further studies are needed to evaluate the long-term effects to better elucidate these impacts.

Keywords: Genetically modifiedSoybean oilHistologyLiverKidneyRats


Please cite this article as follows: Taheri H, Mesgari-Abbasi M, Khordadmehr M, Rahimi Mamaghani A, Abbasalizad-Farhangi M. Effect of genetically modified soybean oil consumption on biochemical and histological changes of liver and kidney in rats. Int J Drug Res Clin. 2024; 2: e11. doi: 10.34172/ijdrc.2024.e11

The Trans Fats and Fake Oils Monster

RFK Jr.’s MAHA Mantra Wins Over Fans by Stoking Food Toxin Fear

Robert F. Kennedy Jr.

Robert F. Kennedy Jr.© Bloomberg

(Bloomberg) — “Make America Great Again” has long been a signature phrase at Donald Trump’s rally speeches. Its recent offshoot, “Make America Healthy Again” or MAHA, is now spreading on social media as fitness influencers and parents embrace a push by Robert F. Kennedy Jr. to clean up US food production.

Kennedy, who has been promised a role in health and food safety by the incoming Trump administration, has long drawn scorn among public health experts who oppose his recommendations to require vaccines and remove fluoride from drinking water, cornerstone public health strategies. He has also advocated for drinking raw milk, which the US Food and Drug Administration warns can cause serious health risks.

But there’s one area that has brought in new supporters: His vows to “dismantle the corporate stranglehold” on the American food supply, a push to remove dyes, pesticides and other toxins from the industry. 

“There are a lot of things about Kennedy’s views about health I’m not very comfortable with – I certainly don’t share his position on vaccination, I don’t share his position on fluoride,” said Marion Nestle, a retired New York University nutrition professor who also writes the Food Politics newsletter. “But he’s absolutely right that chronic disease is a huge problem and conflicts of interest between people in government and food companies are rampant.”

One place Kennedy has promised to start: The artificial dyes used in American kids’ cereals and banned in other parts of the world.

“The first thing I’d do isn’t going to cost you anything because I’m just gonna tell the cereal companies, take all the dyes out of their food,” Kennedy said days before Trump’s presidential election victory. One way to do that is to expand a ban on the dyes that passed in California earlier this year, a measure that has support from a bipartisan group of senators.

Vani Hari, known to her two million Instagram followers as @thefoodbabe, who has long been vocal about the dangers of artificial dyes in foods, now sees momentum to get these issues addressed.  

“I am so thrilled that finally, with Robert F. Kennedy Jr.’s leadership, someone in Washington will start to hold these companies accountable,” Hari said in an interview.

RFK Jr.’s Path

Kennedy’s leadership of the anti-vaccine movement prompted many experts to raise concerns about his statements, saying they are misleading and dangerous to public health. 

But earlier in his career, he was better known for heading Waterkeeper Alliance, which worked to protect New York’s Hudson River and its tributaries from industrial pollution. He was one of the lawyers who won a 2018 lawsuit against Monsanto saying its Roundup weed killer caused cancer. And when he ran for president, agricultural reform was one of his big issues. 

When Kennedy suspended his presidential campaign in August, he backed Trump instead and redirected searches of kennedy2024.com to his MAHA site. Fitness guru Jillian Michaels, comedian Nicole Arbour and other influencers jumped on board.

After Kennedy endorsed Trump, it “activated me to be all-in for ‘Team Trump’ and get my audience all-in for him as well,” Arbour said in an interview. Following Trump’s win, she posted “We did it!!!! Trump and MAHA won!”

Alex Clark, host of the Culture Apothecary wellness podcast, said that when she first posted a link on her Instagram account to get people to register to vote for Trump, it had fewer than a hundred clicks. When she posted the same link after Kennedy endorsed Trump, “thousands and thousands of people” clicked it, she said. 

“I knew immediately that this was a needle-mover for these voters,” she said in an interview. “They see the food and the environmental toxins and poisons affecting their own personal families.”

©2024 Bloomberg L.P.

The Artificial Colors and Flavors Monsters – What’s Eating You Kid?

With RFK Jr. Poised to Assume Key Role in Public Health, Kids Could Finally Have an Ally in Washington

This was an inspiring if turbulent election year for the health freedom movement — and for anyone concerned about the epidemic of chronic disease that is robbing our children of a healthy future. We at CHD support the vision to end the epidemic of chronic disease and look forward to what comes next.

by Mary Holland, J.D.

November 6, 2024

girl holding american flag and RFK Jr.

Whether your candidates won or lost last night, I’m sure most of us can agree: It’s a relief to have the elections behind us.

Still, this was an inspiring if turbulent election year for the health freedom movement — and for anyone concerned about the epidemic of chronic disease that is robbing our children of a healthy future.

To recap the last year-and-a-half — on April 19, 2023, our founder, Robert F. Kennedy Jr., took leave from Children’s Health Defense (CHD) to run for president as a Democrat.

About six months later, he switched gears to run as an independent.

Then, on Aug. 23 of this year, Kennedy, the longtime Democrat, suspended his campaign — and in a move that perhaps even he didn’t see coming — he endorsed former President Donald Trump.

Through it all, Kennedy remained true to his commitment: to end the chronic disease epidemic.

He never wavered. For perhaps the first time in history, Kennedy gave children a voice in a national election.

He reminded anyone who would listen that children are not Democrats or Republicans. They’re kids. They’re “swimming around in a toxic soup.” And they need our help.

With Trump’s support, Kennedy and his team launched the Make American Healthy Again campaign. He vowed to do whatever it takes to get toxic chemicals out of our food, our soil, our water and our air.

He promised to take on the FDA, CDC, HHS, NIH, NIAID, USDA, EPA, FCC — and any other federal agency that puts corporate profits ahead of public health.

Perhaps most importantly, Kennedy promised to get to the bottom of why 1 in 33 children in this country has autism.

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Just last week, Kennedy — a member of Trump’s transition team — said that one of his first jobs, if Trump were elected, would be to gain access to the CDC’s vaccine safety data so his team can analyze it to determine if vaccines are as safe as the FDA and CDC say they are.

As with every election season, we’ve heard a lot of promises over these past months. With the election behind us, we at CHD are hopeful that Trump will keep the promises he made to Kennedy — so Kennedy can keep the promises he made to the American people.

Politics aside, I’m hopeful that 2025 will bring truth and transparency to our public health agencies — and health and prosperity for us and future generations.

CHD’s mission is now more important than ever. And for perhaps the first time, our mission appears to be in alignment with the federal government — to expose harms, seek justice and protect children from toxic exposures.

Mary Holland, J.D.

Mary Holland, J.D.

Mary Holland, J.D. is CEO of Children’s Health Defense. She has been writing and advocating for better vaccine law and policy for many years, including while she served on the faculty at NYU School of Law from 2002-19. She is co-author of two books on vaccines, “Vaccine Epidemic” and “The HPV Vaccine on Trial,” as well as several law review articles.